TARGETING IMMUNE-DRIVEN OPIOID ANALGESIA BY SIGMA-1 RECEPTORS: OPENING THE DOOR TO NOVEL PERSPECTIVES FOR THE ANALGESIC USE OF SIGMA-1 ANTAGONISTS
| Autor: | Ángeles Montilla-García, Rafael González-Cano, Inmaculada Bravo-Caparrós, Miguel Á. Tejada, M. Carmen Ruiz-Cantero, Francisco R. Nieto, Enrique J. Cobos |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Analgesic Pain Inflammation Neurotransmission 03 medical and health sciences 0302 clinical medicine Immune system Dual role immune cells medicine Animals Humans Receptors sigma sigma-1 receptors Molecular Targeted Therapy Opioid peptide Receptor Pharmacology business.industry analgesia Analgesics Opioid neuro-immune interactions 030104 developmental biology Opioid endogenous opioid peptides bacteria Analgesia medicine.symptom business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Digibug. Repositorio Institucional de la Universidad de Granada Consejo Superior de Investigaciones Científicas (CSIC) |
| Popis: | Immune cells have a known role in pronociception, since they release a myriad of inflammatory algogens which interact with neurons to facilitate pain signaling. However, these cells also produce endogenous opioid peptides with analgesic potential. The sigma-1 receptor is a ligand-operated chaperone that modulates neurotransmission by interacting with multiple protein partners, including the µ-opioid receptor. We recently found that sigma-1 antagonists are able to induce opioid analgesia by enhancing the action of endogenous opioid peptides of immune origin during inflammation. This opioid analgesia is seen only at the inflamed site, where immune cells naturally accumulate. In this article we review the difficulties of targeting the opioid system for selective pain relief, and discuss the dual role of immune cells in pain and analgesia. Our discussion creates perspectives for possible novel therapeutic uses of sigma-1 antagonists as agents able to maximize the analgesic potential of the immune system University of Granada Martín Escudero postdoctoral program FPU grants from the Spanish Ministry of Economy and Competitiveness (MINECO) Juan de la Cierva-Incorporación postdoctoral grant from MINECO MINECO [grant number SAF2016-80540-R] Junta de Andalucía (grant CTS109) FEDER funds |
| Databáze: | OpenAIRE |
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