Rapid permissive action of dexamethasone on the regulation of blood pressure in a rat model of septic shock

Autor: Chun-Lei Jiang, Zhou Jiangrui, Wen-Lei Shi, Yong-Hua Huang, Ting Zhang
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
endocrine system
medicine.medical_specialty
Time Factors
Vascular smooth muscle
Myocytes
Smooth Muscle
Blood Pressure
Punctures
Dexamethasone
Muscle
Smooth
Vascular
Rats
Sprague-Dawley
Norepinephrine (medication)
Norepinephrine
03 medical and health sciences
0302 clinical medicine
Glucocorticoid receptor
Internal medicine
polycyclic compounds
medicine
Animals
Vasoconstrictor Agents
Permissive
Cecum
Glucocorticoids
Ligation
Mesenteric arteries
Cells
Cultured
Pharmacology
Septic shock
business.industry
Adrenalectomy
General Medicine
Actin cytoskeleton
medicine.disease
Shock
Septic
Mesenteric Arteries
Actin Cytoskeleton
Disease Models
Animal
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Vasoconstriction
030220 oncology & carcinogenesis
business
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Zdroj: Biomedicine & Pharmacotherapy. 84:1119-1125
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2016.10.029
Popis: Glucocorticoids (GCs) play a vital role in the regulation of blood pressure by their permissive effects in potentiating vasoactive responses to catecholamines through glucocorticoid receptors. GCs achieve this function by controlling vascular smooth muscle tone. Clinically, low to moderate doses of GCs are generally used in the treatment of septic shock in recent years. GCs are now known to have both genomic and non-genomic effects. While genomic effects of GCs were well studied, few non-genomic effects were reported, much less the non-genomic mechanisms. One of the most important characters of their non-genomic effects is short latency. The aim of this study was to determine whether GCs can rapidly regulate blood pressure by their permissive action on norepinephrine (NE). Adrenalectomized rats were subjected to cecal ligation and puncture to induce septic shock. The septic rats displayed a significant decrease in the blood pressure response to NE. Dexamethasone (DEX) rapidly restores this hyporeactivity to NE in adrenalectomized septic rats. Further studies showed that DEX potentiates the NE-induced shrinkage and actin cytoskeleton rearrangement of single cell from mesenteric arteries in a short time. These findings suggest that GCs probably exert their permissive actions on the pressure response to NE through rapid non-genomic mechanisms. In this article, we found that as an adjunctive therapy for septic shock, the use of GCs may involve a rapid permissive action, and non-genomic effects of GCs may be involved in these processes.
Databáze: OpenAIRE
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