MASS SPECTROMETRY ANALYSIS OF DRUGS OF ABUSE: CHALLENGES AND EMERGING STRATEGIES
| Autor: | Veronica Termopoli, Achille Cappiello, Pierangela Palma, Scott A. Borden, Giorgio Famiglini, Chris G. Gill, Jan Palaty |
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| Přispěvatelé: | Borden, S, Palaty, J, Termopoli, V, Famiglini, G, Cappiello, A, Gill, C, Palma, P |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drugs of abuse Liquid Phase Microextraction Mass spectrometry Sensitivity and Specificity 01 natural sciences Gas Chromatography-Mass Spectrometry Mass Spectrometry General Biochemistry Genetics and Molecular Biology Analytical Chemistry Mass spetrometry drugs of abuse 03 medical and health sciences CHIM/01 - CHIMICA ANALITICA Environmental health Humans Solid Phase Microextraction Spectroscopy Ambient ionization Illicit Drugs Chemistry 010401 analytical chemistry Forensic Medicine Condensed Matter Physics 0104 chemical sciences Substance Abuse Detection 030104 developmental biology Chromatography Liquid |
| Popis: | Mass spectrometry has been the "gold standard" for drugs of abuse (DoA) analysis for many decades because of the selectivity and sensitivity it affords. Recent progress in all aspects of mass spectrometry has seen significant developments in the field of DoA analysis. Mass spectrometry is particularly well suited to address the rapidly proliferating number of very high potency, novel psychoactive substances that are causing an alarming number of fatalities worldwide. This review surveys advancements in the areas of sample preparation, gas and liquid chromatography-mass spectrometry, as well as the rapidly emerging field of ambient ionization mass spectrometry. We have predominantly targeted literature progress over the past ten years and present our outlook for the future. © 2020 Periodicals, Inc. Mass Spec Rev. |
| Databáze: | OpenAIRE |
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