Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports
| Autor: | Remi Goto-Semba, Chikage Oshita, Tomohiro Ueda, Hiroki Teragawa, Yuichi Fujii |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Case Report Vasodilation 030204 cardiovascular system & hematology Angina 03 medical and health sciences Refractory chest pain 0302 clinical medicine Internal medicine parasitic diseases medicine Generic drugs In patient cardiovascular diseases 030212 general & internal medicine health care economics and organizations Vasospastic angina Brand names business.industry medicine.disease Acetylcholine Brand-name drugs Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | World Journal of Cardiology |
| ISSN: | 1949-8462 |
| DOI: | 10.4330/wjc.v10.i3.15 |
| Popis: | It is well known that calcium channel blockers (CCBs) are the first line of therapy for vasospastic angina (VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. In both cases, angina recurred upon switching from a brand-name CCB to a generic CCB during follow-up. The patients’ condition improved upon switching back to the original CCB. Both cases involved a high severity of VSA, based on the results of spasm provocation testing. These findings suggest that, in some patients with severe VSA, the frequency of angina attacks increases when switching from a brand-name CCB to a generic CCB. Cardiologists should consider this factor when prescribing drugs for angina. |
| Databáze: | OpenAIRE |
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