The effects of prostaglandins PGE1, PGE2, PGF1a, and PGF2a on canine synovial perfusion
| Autor: | I.J. Zeitlin, W.C. Dick, W.W. Buchanan, D.M. Grennan, W.S. Mitchell |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Xenon Prostaglandin Antagonists Stimulation Vasodilation Biochemistry Microcirculation Dogs Endocrinology Vasoactive Internal medicine medicine Animals Chemistry Prostaglandins E Prostaglandins F Synovial Membrane Half-life Diphloretin phosphate respiratory system Stimulation Chemical High dosage lipids (amino acids peptides and proteins) Perfusion Half-Life circulatory and respiratory physiology |
| Zdroj: | Prostaglandins. 9:799-816 |
| ISSN: | 0090-6980 |
| DOI: | 10.1016/0090-6980(75)90115-x |
| Popis: | In these experiments we have examined the effects of PGE1, PGE2, PGF1alpha and PGF2alpha on synovial perfusion in the normal canine synovial microcirculation. The effects of the drugs on synovial perfusion were determined indirectly from the changes produced in the rate of clearance of 133Xenon from the joint by their intra-articular injection. Prostaglandins PGE1 and PGE2 were found to be strongly vasodilator with PGE1 being the more active. PGF1alpha appeared to have little or no vasoactive properties in doses up to 1 ugm. (2.8 times 10(-5M)) in our preparation while PGF2alpha was vasodilator at this high dosage only. Neither SC19920 nor diphloretin phosphate antagonished the effects of PGE1 in these experiments. |
| Databáze: | OpenAIRE |
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