Perinatal follow-up of children born after preimplantation genetic diagnosis between 1995 and 2014

Autor: Aimee D C Paulussen, Christine E. M. de Die-Smulders, N. D. Muntjewerff, Frank J.M. Broekmans, Marieke van Deursen-Luijten, John J.M. Engelen, Yvonne Arens, Jos Dreesen, M. Meijer-Hoogeveen, Aafke P.A. van Montfoort, Malou Heijligers, Edith Coonen, Mark A. H. B. M. van der Hoeven, Katelijne Bouman, Ron J. T. van Golde, I. Homminga, Andrea Peeters, Vyne van der Schoot
Přispěvatelé: MUMC+: KIO Kemta (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Polikliniek (9), Obstetrie & Gynaecologie, MUMC+: DA KG Lab Centraal Lab (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Klinische Genetica, MUMC+: VMK IVF Lab (9), MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9)
Rok vydání: 2018
Předmět:
Male
Time Factors
Abortion
0302 clinical medicine
Pregnancy
Prospective Studies
030212 general & internal medicine
Assisted Reproduction Technologies
Child
Children
Genetics (clinical)
Congenital malformations
OUTCOMES
030219 obstetrics & reproductive medicine
NEWBORNS
Obstetrics
Follow-up
Incidence (epidemiology)
Preimplantation genetic diagnosis
Obstetrics and Gynecology
General Medicine
Perinatal Care
Gestation
Female
MISDIAGNOSIS
medicine.symptom
Adult
medicine.medical_specialty
Birth weight
Reproductive medicine
Congenital Abnormalities
03 medical and health sciences
ESHRE PGD CONSORTIUM
PREGNANCIES
Genetics
medicine
Humans
Genetic Testing
Diagnostic Errors
Preimplantation Diagnosis
METAANALYSIS
Fetus
ANEUPLOIDY
business.industry
Infant
Newborn
Perinatal outcome
BLASTOMERE
BIRTH-WEIGHT
Low birth weight
Reproductive Medicine
HUMAN EMBRYOS
business
Follow-Up Studies
Developmental Biology
Zdroj: Journal of Assisted Reproduction and Genetics, 35(11), 1995-2002. Springer
Journal of Assisted Reproduction and Genetics
Journal of Assisted Reproduction and Genetics, 35(11), 1995-2002. SPRINGER/PLENUM PUBLISHERS
ISSN: 1573-7330
1058-0468
DOI: 10.1007/s10815-018-1286-2
Popis: Purpose We aim to evaluate the safety of PGD. We focus on the congenital malformation rate and additionally report on adverse perinatal outcome. Methods We collated data from a large group of singletons and multiples born after PGD between 1995 and 2014. Data on congenital malformation rates in live born children and terminated pregnancies, misdiagnosis rate, birth parameters, perinatal mortality, and hospital admissions were prospectively collected by questionnaires. Results Four hundred thirty-nine pregnancies in 381 women resulted in 364 live born children. Nine children (2.5%) had major malformations. This percentage is consistent with other PGD cohorts and comparable to the prevalence reported by the European Surveillance of Congenital Anomalies (EUROCAT). We reported one misdiagnosis resulting in a spontaneous abortion of a fetus with an unbalanced chromosome pattern. 20% of the children were born premature (
Databáze: OpenAIRE
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