Prognostic significance of neuron-associated protein expression in non-muscle-invasive urothelial bladder cancer

Autor: Richard T. Cheney, Paulette Mhawech-Fauceglia, François Herrmann, L. Ali, J Groth
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Male
Cytoplasm
Pathology
Tumor Markers
Biological/*metabolism
Nerve Growth Factors/metabolism
Neuropilin
Medicine
Aged
80 and over
Univariate analysis
Tissue microarray
Cell adhesion molecule
Anatomical pathology
General Medicine
Middle Aged
Prognosis
Neoplasm Proteins
Cytoplasm/metabolism
Cell Adhesion Molecules
Neuronal/metabolism
Disease Progression
Female
Adult
medicine.medical_specialty
Cell Adhesion Molecules
Neuronal
Synucleins
Nerve Tissue Proteins
Nerve Tissue Proteins/*metabolism
Pathology and Forensic Medicine
Biomarkers
Tumor
Humans
Neoplasm Proteins/metabolism
Neoplasm Invasiveness
Nerve Growth Factors
Tissue Array Analysis/methods
Aged
Neoplasm Staging
Urinary Bladder Neoplasms/*metabolism/pathology
Bladder cancer
business.industry
Cancer
medicine.disease
ddc:616.8
Urinary Bladder Neoplasms
Tissue Array Analysis
ddc:618.97
Synuclein
Cancer research
Synucleins/metabolism
business
Epidemiologic Methods
Zdroj: Journal of Clinical Pathology, Vol. 62, No 8 (2009) pp. 710-714
ISSN: 0021-9746
Popis: Background: Numerous novel genes have been identified in urothelial bladder cancer (UBC); genes including ninjurin, synuclein and neuropilin seem to be associated with invasive tumours and aggressive behaviour. Aims: To define the protein expression of these biomarkers and to reveal their prognostic value in a large series of superficial (pTa) and minimally invasive (pT1) cases of UBC with a long and adequate follow-up. Methods: Tissue microarray was done on 183 paraffin-embedded tumour tissues (pTa 81, pT1 102). Statistical analysis was performed to define the association between each of these biomarkers, clinical data and tumour outcomes. Results: There was a statistically significant association between synuclein expression and tumour stage (p = 0.029). Ninjurin expression was significantly associated with tumour progression in univariate analysis. Tumour grade seemed to have an independent value in predicting tumour recurrence and progression. Conclusion: Tumours with strong synuclein expressions are more likely to be more advanced tumours (pT1). Tumours expressing ninjurin tend to progress slower than those with no ninjurin expressions. Synuclein and neuropilin failed to show any value in predicting tumour behaviour.
Databáze: OpenAIRE
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