Amelioration of Painful Crises in Sickle Cell Disease by Venesections
| Autor: | Thomas Tassiopoulos, Kostas Konstantopoulos, Revekka Tzanetea, Vassiliki Kalotychou, Yannis Rombos, Phaedon Fessas, Athanasios Aessopos, Spyros Simitzis |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Erythrocyte Indices Male Pediatrics medicine.medical_specialty Genotype Pain Anemia Sickle Cell Disease Humans Pain Management Medicine Molecular Biology Bloodletting Retrospective Studies business.industry Conventional treatment Cell Biology Hematology Iron deficiency Middle Aged medicine.disease Home Care Services Surgery Hospitalization Ferritins Molecular Medicine Female business Follow-Up Studies Blood drawing |
| Zdroj: | Blood Cells, Molecules, and Diseases. 28:283-287 |
| ISSN: | 1079-9796 |
| DOI: | 10.1006/bcmd.2002.0489 |
| Popis: | ABSTRACT Sickle cell disease patients who acquire iron deficiency may experience a degree of amelioration from painful crises in terms of frequency, severity, and duration. This observation prompted us to identify the potential utility of iron load reduction in the management of this disease. Thirteen sickle cell patients not ameliorated by conventional treatment entered a weekly venesection protocol. Hematological values and painful crises of all degrees of severity were recorded and compared to those of the last 12 months before venesection for each case separately (“historical controls”). A decrease was noted in the frequency and intensity of several types of painful crises. Reduction of iron load by venesection seems to be a simple, safe, side-effect-free, and efficient way of preventing and ameliorating to a large extent painful crises in sickle cell disease. The biological effects of venesection on other parameters of sickle cell disease remain to be determined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect