Local anaesthetics inhibit influx of calcium, sodium and potassium into rat ileum, diaphragm and human isolated saphenous vein
| Autor: | A.H. Suer, A.C. Tugwell, E. Greenidge, A. Hayter, F. A. Wali |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Etidocaine Potassium Diaphragm Mepivacaine chemistry.chemical_element Ileum In Vitro Techniques Calcium Internal medicine medicine Animals Humans Saphenous Vein Anesthetics Local Pharmacology Bupivacaine Dose-Response Relationship Drug Muscles Sodium Skeletal muscle Rats Inbred Strains Rats Endocrinology medicine.anatomical_structure chemistry Anesthesia Verapamil medicine.drug |
| Zdroj: | General Pharmacology: The Vascular System. 18:351-355 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/0306-3623(87)90090-5 |
| Popis: | 1. 1. The effects of 5 different local anaesthetics, lignocaine, prilocaine, etidocaine, mepivacaine, bupivacaine, on uptake of Ca2+, Na+ and K+ were studied, using a Kone Microlyte Analyzer, into 3 different types of muscle fibres, the rat ileum, rat diaphragm and human isolated saphenous vein. 2. 2. The aim of the present experiments was to see if local anaesthetics had a calcium antagonistic activity, like that produced by calcium antagonists, e.g. verapamil. 3. 3. The results showed that local anaesthetics in moderate and high concentrations (more than 100 μM) depressed uptake of Ca2+, as well as the Na+ and K+, although the depression of the uptake of Ca2+ was 7 and 2 times less than those of Na+ and K+. 4. 4. In low concentrations (1–10 μM), the local anaesthetics had no or little effect on Ca2+ uptake, although they still significantly reduced Na+ and K+ uptake. 5. 5. It was concluded that the effect of local anaesthetics on uptake of Ca2+, Na+ and K+ into rat ileum, diaphragm and human saphenous vein, is concentration-dependent, and that only at high concentrations do they have a calcium antagonistic activity in muscle. 6. 6. Furthermore, there was no clear evidence that the effect of local anaesthetics was species-dependent, since the uptake of Ca2+ was depressed by only about 17% more in smooth muscle than in skeletal muscle. |
| Databáze: | OpenAIRE |
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