Histochemical and morphological aspects of fresh frozen bone: a preliminary study
| Autor: | Giovanna Vermiglio, Angelo Favaloro, Antonio Centofanti, F.S. De Ponte, Giuseppina Cutroneo, Giuseppe Anastasi, Michele Runci, Giuseppina Rizzo, Roberto Falzea, Luciano Catalfamo |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Histology fluorescence antibody technique histological techniques Biophysics Dentistry Bone healing Fresh frozen bone Matrix (biology) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Osteoclast medicine Maxilla Humans Fluorescence antibody technique Histological techniques Osteoblast VEGF Female Bone Transplantation Cryopreservation Cell Biology lcsh:QH301-705.5 biology business.industry Brief Report 030229 sport sciences 030206 dentistry Vascular endothelial growth factor medicine.anatomical_structure chemistry lcsh:Biology (General) Osteocyte osteoclast Osteocalcin biology.protein osteoblast Implant business |
| Zdroj: | European Journal of Histochemistry, Vol 60, Iss 4 (2016) European Journal of Histochemistry : EJH |
| ISSN: | 2038-8306 |
| Popis: | Bone graft are used in dentistry for the reconstruction of severely atrophic jaws. Fresh frozen bone has no osteogenic property but it has osteoconductive and osteoinductive properties because its matrix contains growth factors such as vascular endothelial growth factor. The purpose of the present study was to evaluate morphological and protein expression characteristics of fresh frozen bone before graft and after six months of graft in patients who needed maxillary reconstruction. After 6 month of graft we observed the presence of viable bone as evidenced by full osteocyte lacunae and by the presence of RANKR, osteocalcin positive cells and vascular endothelial growth factor. In conclusion, our findings show that the fresh frozen bone after six month of graft is for the most part viable bone, encouraging its use as an alternative to autogenous bone for reconstructing maxillary bone defects prior to implant. |
| Databáze: | OpenAIRE |
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