Regeneration of mandibular osteoradionecrosis with autologous cross-linked serum albumin scaffold
| Autor: | Lorena Gallego, Luis Junquera, Luis García-Consuegra, Alvaro Meana, Antonio Martinez |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Embryology medicine.medical_specialty Osteoradionecrosis medicine.medical_treatment Biomedical Engineering Serum albumin 03 medical and health sciences 0302 clinical medicine Refractory Tissue engineering medicine Humans Regeneration Mandibular Diseases Bone regeneration Serum Albumin Aged Aged 80 and over Tissue Scaffolds biology business.industry Regeneration (biology) 030206 dentistry medicine.disease Surgery Radiation therapy 030220 oncology & carcinogenesis biology.protein business Wound healing |
| Zdroj: | Regenerative Medicine. 15:1841-1849 |
| ISSN: | 1746-076X 1746-0751 |
| DOI: | 10.2217/rme-2020-0042 |
| Popis: | Osteoradionecrosis is one of the most severe complications of radiotherapy administered for head and neck tumors. We present the first two cases of advanced and refractory mandibular osteoradionecrosis treated by application of a novel autologous cross-linked 3D serum matrix. Patients were followed clinically and radiographically up to 24 months. Complete wound healing and intact mucosal cover were achieved in both cases. At 12 months, the radiographic values showed an almost complete regeneration of the bone defect, which continued a favourable progression increased to the maximum by 24 months after surgery. The use of an autologous serum-derived scaffold proved to be a quick, predictable, cost-effective and safe adjunct to the conservative surgical treatment of this pathology. |
| Databáze: | OpenAIRE |
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