Cerebrospinal creatinine kinase level in children with meningitis
| Autor: | Waleed Tamimi, Ali Al-Khulif, Norah Hamad Al-Kharji, Khalid Khalaf Alharbi, Naila Felimban, Melfi Alanazi |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Clinical Biochemistry medicine.disease_cause Gastroenterology Sensitivity and Specificity Spinal Puncture Meningitis Bacterial Cerebrospinal fluid Predictive Value of Tests Positive predicative value Internal medicine Creatine Kinase BB Form Medicine Humans Meningitis Aseptic Child Creatine Kinase CSF albumin biology business.industry Streptococcus Aseptic meningitis Cerebrospinal Fluid Proteins General Medicine Clinical Enzyme Tests medicine.disease Pneumonia Endocrinology Glucose biology.protein Creatine kinase Female business Meningitis |
| Zdroj: | Clinical biochemistry. 41(12) |
| ISSN: | 1873-2933 |
| Popis: | Background The aim of this study is to evaluate the diagnostic value of the enzyme creatine kinase (CK) in the cerebrospinal fluid (CSF) of children with meningitis. Method CSF samples were collected from seventy one children suspected of having meningitis. The levels of total CK, CK-BB, Glucose, total protein, WBC counts, and culture were determined in the CSF. The cutoff value for total CK in the CSF was defined as 18 U/L. Results Three cases (4%) of bacterial meningitis and 11 cases (15%) of aseptic meningitis were confirmed by culture. The sensitivity and specificity of total CK CSF level alone to diagnose bacterial meningitis were found to be 33% and 91% respectively. The positive and negative predictive values were found to be 14% and 98% respectively. On the other hand, the sensitivity and specificity of total CK level in aseptic meningitis were found to be 40% and 98% respectively and the positive and negative predictive values were 86% and 94% respectively. The sensitivity and specificity of total protein and glucose in CSF were also calculated. Streptococcus pneumonia and homophiles influenza were the main types identified in our cases. Discussion and conclusion Measuring the total CK level in the CSF may be very useful in diagnosis of meningitis if only combined with other CSF markers. It is not of any much benefit if it is used solely. |
| Databáze: | OpenAIRE |
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