3D powder printed tetracalcium phosphate scaffold with phytic acid binder: fabrication, microstructure and in situ X-Ray tomography analysis of compressive failure
| Autor: | Uwe Gbureck, Bikramjit Basu, Sourav Mandal, Susanne Meininger |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Calcium Phosphates
Materials science X-ray microtomography Compressive Strength Phytic Acid Biomedical Engineering Biophysics Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Weight-Bearing Biomaterials chemistry.chemical_compound Materials Testing Ceramic Composite material Porosity Tissue Engineering Tissue Scaffolds Tetracalcium phosphate ttcp X-Ray Microtomography 021001 nanoscience & nanotechnology Compression (physics) Microstructure 0104 chemical sciences Compressive strength chemistry visual_art Bone Substitutes Printing Three-Dimensional visual_art.visual_art_medium Powders 0210 nano-technology |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 29 |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-018-6034-8 |
| Popis: | One of the important aspects in 3D powder printing (3DPP) is the selection of binder for a specific material composition to produce scaffolds with desired microstructure and physico-chemical properties. To this end, a new powder-binder combination, namely tetracalcium phosphate (TTCP) and phytic acid (IP6) was investigated at ambient temperature, for low load bearing application. A minimal deviation (< 200 mu m, w.r.t. computer aided design) was observed in the final sample through optimization of 3DPP process, along with minimum strut and macro-pore size of 200 and 750 mu m, respectively. Importantly, the printed scaffolds exhibited compressive strength of 4-8.5 MPa (in the range of cancellous bone) and in vitro dissolution experiments in phosphate buffered saline (PBS) upto one month revealed gradual degradation in strength property. The TTCP scaffolds are characterized to be moderately porous (similar to 40%) with high interconnectivity, which is essential for vascularization and good osteoconductivity. Another major aim of this study was to demonstrate the failure mechanism of 3D powder-printed scaffolds using monotonic and intermittent compression coupled with micro-computed tomography (mu CT) imaging. these results, we have demonstrated the origin of crack generation and propagation under compressive loading in relation to the unique microstructure, obtained through 3DPP. These findings enable us to acquire a deeper insight of the relationship between structural attributes and failure behavior, to further tailor the 3D powder printing process for ceramic biomaterials. GRAPHICS] . |
| Databáze: | OpenAIRE |
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