Nutritional factors and susceptibility to arsenic-caused skin lesions in West Bengal, India
| Autor: | Meera M. Hira Smith, Arindam Basu, D N Guha Mazumder, Nilima Ghosh, Ondine S. von Ehrenstein, Sambit Samanta, Gladys Block, Soma Mitra, Reina Haque, Allan H. Smith |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Pathology Cross-sectional study Health Toxicology and Mutagenesis Physiology Arsenic poisoning environmental health Skin Pigmentation 010501 environmental sciences Toxicology Medical and Health Sciences 01 natural sciences Risk Factors Prevalence Medicine 2. Zero hunger 0303 health sciences education.field_of_study nutritional susceptibility Micronutrient 3. Good health Nutrition Disorders Female Adult medicine.medical_specialty Population chemistry.chemical_element India Nutritional Status skin lesions Article Environmental Medicine 03 medical and health sciences Arsenic Poisoning Humans education Arsenic 030304 developmental biology 0105 earth and related environmental sciences business.industry Public Health Environmental and Occupational Health Case-control study arsenic case–control study Odds ratio Keratosis medicine.disease Health Surveys Malnutrition Cross-Sectional Studies chemistry Case-Control Studies business Environmental Sciences |
| Zdroj: | Environmental Health Perspectives Environmental health perspectives, vol 112, iss 10 |
| ISSN: | 0091-6765 |
| Popis: | There has been widespread speculation about whether nutritional deficiencies increase the susceptibility to arsenic health effects. This is the first study to investigate whether dietary micronutrient and macronutrient intake modulates the well-established human risk of arsenic-induced skin lesions, including alterations in skin pigmentation and keratoses. The study was conducted in West Bengal, India, which along with Bangladesh constitutes the largest population in the world exposed to arsenic from drinking water. In this case-control study design, cases were patients with arsenic-induced skin lesions and had < 500 microg/L arsenic in their drinking water. For each case, an age- and sex-matched control was selected from participants of a 1995-1996 cross-sectional survey, whose drinking water at that time also contained < 500 microg/L arsenic. Nutritional assessment was based on a 24-hr recall for major dietary constituents and a 1-week recall for less common constituents. Modest increases in risk were related to being in the lowest quintiles of intake of animal protein [odds ratio (OR) = 1.94; 95% confidence interval (CI), 1.05-3.59], calcium (OR = 1.89; 95% CI, 1.04-3.43), fiber (OR = 2.20; 95% CI, 1.15-4.21), and folate (OR = 1.67; 95% CI, 0.87-3.2). Conditional logistic regression suggested that the strongest associations were with low calcium, low animal protein, low folate, and low fiber intake. Nutrient intake was not related to arsenic exposure. We conclude that low intake of calcium, animal protein, folate, and fiber may increase susceptibility to arsenic-caused skin lesions. However, in light of the small magnitude of increased risks related to these dietary deficiencies, prevention should focus on reducing exposure to arsenic. |
| Databáze: | OpenAIRE |
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