The influence of hydrostatic pressure on tissue engineered bone development
| Autor: | Jonathan P. Whiteley, K H L Neßler, Sarah L. Waters, A.J. El Haj, James M. Osborne, James R. Henstock |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Statistics and Probability 0206 medical engineering Hydrostatic pressure 02 engineering and technology Bone tissue Models Biological General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Pore water pressure Mechanobiology Calcification Physiologic Tissue engineering Bone cell Hydrostatic Pressure Bioreactor medicine Shear stress Computer Simulation Minerals Bone Development Tissue Engineering General Immunology and Microbiology Applied Mathematics General Medicine R1 020601 biomedical engineering 030104 developmental biology medicine.anatomical_structure Modeling and Simulation General Agricultural and Biological Sciences Biomedical engineering |
| Zdroj: | Journal of Theoretical Biology. 394:149-159 |
| ISSN: | 0022-5193 1095-8541 |
| Popis: | The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; (i) a component describing the cell memory of the applied stimulation, and (ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation. |
| Databáze: | OpenAIRE |
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