Appendectomy, smoking habits and the risk of developing ulcerative colitis: a case control study in private practice setting
| Autor: | Gil-Rch, Yoram Bouhnik, Pierre Clerson, Philippe de Saussure, Pierre-Louis Prost, Nghiep Truong Tan |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Smoking habit Single visit Cigarette smoking Crohn Disease Recurrence Risk Factors Internal medicine medicine Appendectomy Humans In patient Risk factor Glucocorticoids business.industry Smoking Gastroenterology Case-control study General Medicine Colonoscopy medicine.disease Ulcerative colitis Surgery Private practice Case-Control Studies Colitis Ulcerative Female business Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | Gastroenterologie clinique et biologique. 31(5) |
| ISSN: | 0399-8320 |
| Popis: | The strongest environmental factors identified for ulcerative colitis (UC) are cigarette smoking and appendectomy. However, most studies have been performed using case-controls from hospital-based populations. The purpose of this study was to compare the history of previous appendectomy and smoking habits in a group of patients with UC and a control group, followed by gastroenterologists in private practice.We performed a case control study in which 100 physicians recruited UC-patients and age and sex matched controls. Data were collected during a single visit. Based on a standardized questionnaire, UC patients and controls were divided into never, former or current smokers, and into subjects with or without a previous history of appendectomy.One hundred and ninety eight age- and sex-matched pairs of UC patients and controls were included. The prevalence of appendectomy in the UC-patients and control group was 12% and 46%, respectively. The pairwise-matched OR of ulcerative colitis for previous appendectomy was 0.10 (95% CI, 0.05-0.21) (P0.0001). The OR for former and never smokers versus current smokers was 2.40 (95% CI 1.31-4.38) (P=0.004). In UC-patients, the OR of family history of UC compared with controls was 2.80 (95% CI, 1.01-7.77) (P=0.048).This case-control study confirmed a strong negative correlation between both appendectomy and tobacco smoking, and ulcerative colitis in patients followed-up by gastroenterological practitioners. |
| Databáze: | OpenAIRE |
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