Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
| Autor: | Noor U H Mohammed, Francisco Leyva, Harald Sandman, Shajil Chalil, Zaheer Yousef, Paul William Foley, Kayvan Khadjooi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Time Factors Brachial Artery Magnetic Resonance Imaging Cine Arterial Occlusive Diseases Angina Pectoris Electrocardiography Ventricular Dysfunction Left Internal medicine medicine Humans cardiovascular diseases Family history Stroke Angiology Isolated Noncompaction of the Ventricular Myocardium medicine.diagnostic_test business.industry Magnetic resonance imaging Arrhythmias Cardiac Stroke Volume Stroke volume Middle Aged medicine.disease Echoencephalography Cardiac surgery Dyspnea lcsh:RC666-701 Case-Control Studies Cardiology RC Internal medicine cardiovascular system Female Cardiology and Cardiovascular Medicine business Pulmonary Embolism Research Article |
| Zdroj: | BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 9, Iss 1, p 37 (2009) |
| ISSN: | 1471-2261 |
| Popis: | Background It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. Methods Forty two patients, aged 48.7 ± 2.3 yrs (mean ± SEM) underwent cardiovascular magnetic resonance (CMR) for the quantification of left ventricular volumes and extent of non-compacted (NC) myocardium. The latter was quantified using planimetry on the two-chamber long axis LV view (NC area). The patients included those referred specifically for CMR to investigate suspected cardiomyopathy, and as such is represents a selected group of patients. Results At presentation, 50% had dyspnoea, 19% chest pain, 14% palpitations and 5% stroke. Pulmonary embolism had occurred in 7% and brachial artery embolism in 2%. The ECG was abnormal in 81% and atrial fibrillation occurred in 29%. Transthoracic echocardiograms showed features of NC in only 10%. On CMR, patients who presented with dyspnoea had greater left ventricular volumes (both p < 0.0001) and a lower left ventricular ejection fraction (LVEF) (p < 0.0001) than age-matched, healthy controls. In patients without dyspnoea (n = 21), NC area correlated positively with end-diastolic volume (r = 0.52, p = 0.0184) and end-systolic volume (r = 0.56, p = 0.0095), and negatively with EF (r = -0.72, p = 0.0001). Conclusion Left ventricular non-compaction is associated with dysrrhythmias, thromboembolic events, chest pain and LV dysfunction. The inverse correlation between NC area and EF suggests that NC contributes to left ventricular dysfunction. |
| Databáze: | OpenAIRE |
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