Advances in Functionalized Photosensitive Polymeric Nanocarriers
| Autor: | Jahir Orozco, Maritza Fernandez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Polymers and Plastics
Chemistry Bioactive molecules Polymeric nanocarriers polymer nanocarrier Organic chemistry Nanotechnology 02 engineering and technology General Chemistry Review Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences QD241-441 Targeted drug delivery functional nanoparticle On demand light-responsive drug delivery Nanocarriers 0210 nano-technology photoresponsive nanoparticle |
| Zdroj: | Polymers Polymers, Vol 13, Iss 2464, p 2464 (2021) |
| ISSN: | 2073-4360 |
| Popis: | The synthesis of light-responsive nanocarriers (LRNs) with a variety of surface functional groups and/or ligands has been intensively explored for space-temporal controlled cargo release. LRNs have been designed on demand for photodynamic-, photothermal-, chemo-, and radiotherapy, protected delivery of bioactive molecules, such as smart drug delivery systems and for theranostic duties. LRNs trigger the release of cargo by a light stimulus. The idea of modifying LRNs with different moieties and ligands search for site-specific cargo delivery imparting stealth effects and/or eliciting specific cellular interactions to improve the nanosystems’ safety and efficacy. This work reviews photoresponsive polymeric nanocarriers and photo-stimulation mechanisms, surface chemistry to link ligands and characterization of the resultant nanosystems. It summarizes the interesting biomedical applications of functionalized photo-controlled nanocarriers, highlighting the current challenges and opportunities of such high-performance photo-triggered delivery systems. |
| Databáze: | OpenAIRE |
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