Retinal nerve fiber layer measurements by scanning laser polarimetry with enhanced corneal compensation in healthy subjects
| Autor: | Sirisha Senthil, Harsha L. Rao, Ravi K. Yadav, Uday K. Addepalli, Aarthi Jude, Kelli Vidyasagar, Chandra S. Garudadri, Chirravuri R. Venkatesh |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Retinal Ganglion Cells medicine.medical_specialty Aging genetic structures Coefficient of variation Optic Disk Nerve fiber layer Scanning laser polarimetry Glaucoma Nerve fiber Cornea chemistry.chemical_compound Young Adult Nerve Fibers Ophthalmology medicine Humans Intraocular Pressure Aged Birefringence business.industry Healthy subjects Retinal Repeatability Middle Aged medicine.disease eye diseases Healthy Volunteers Axial Length Eye medicine.anatomical_structure Cross-Sectional Studies chemistry Scanning Laser Polarimetry Female sense organs Visual Fields business |
| Zdroj: | Journal of glaucoma. 23(9) |
| ISSN: | 1536-481X |
| Popis: | PURPOSE To evaluate the (i) effects of biological (age and axial length) and instrument-related [typical scan score (TSS) and corneal birefringence] parameters on the retinal nerve fiber layer (RNFL) measurements and (ii) repeatability of RNFL measurements with the enhanced corneal compensation (ECC) protocol of scanning laser polarimetry (SLP) in healthy subjects. METHODS In a cross-sectional study, 140 eyes of 73 healthy subjects underwent RNFL imaging with the ECC protocol of SLP. Linear mixed modeling methods were used to evaluate the effects of age, axial length, TSS, and corneal birefringence on RNFL measurements. One randomly selected eye of 48 subjects from the cohort underwent 3 serial scans during the same session to determine the repeatability. RESULTS Age significantly influenced all RNFL measurements. RNFL measurements decreased by 1 µm for every decade increase in age. TSS affected the overall average RNFL measurement (β=-0.62, P=0.003), whereas residual anterior segment retardance affected the superior quadrant measurement (β=1.14, P=0.01). Axial length and corneal birefringence measurements did not influence RNFL measurements. Repeatability, as assessed by the coefficient of variation, ranged between 1.7% for the overall average RNFL measurement and 11.4% for th nerve fiber indicator. CONCLUSIONS Age significantly affected all RNFL measurements with the ECC protocol of SLP, whereas TSS and residual anterior segment retardance affected the overall average and the superior average RNFL measurements, respectively. Axial length and corneal birefringence measurements did not influence any RNFL measurements. RNFL measurements had good intrasession repeatability. These results are important while evaluating the change in structural measurements over time in glaucoma patients. |
| Databáze: | OpenAIRE |
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