Retinal Functional and Structural Neural Indices: Potential Biomarkers for the Monitoring of Cerebral Neurodegeneration: The Maastricht Study

Autor: van der Heide, Frank C T, Mokhtar, Sara, Khanna, Anjani, Said, Mozhda, Henry, Ronald M A, Kroon, Abraham A, Dagnelie, Pieter C, Eussen, Simone J P M, Berendschot, Tos T J M, Schouten, Jan S A G, Schram, Miranda T, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Wesselius, Anke, Savelberg, Hans H C M, Schaper, Nicolaas C, Webers, Carroll A B, Stehouwer, Coen D A
Přispěvatelé: RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Interne Geneeskunde, RS: MHeNs - R3 - Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: HVC Pieken Maastricht Studie (8), RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Nutrition and Movement Sciences, MUMC+: MA Endocrinologie (9), MUMC+: University Eye Center Maastricht (3), MUMC+: *MA Oogheelkunde (3), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), MUMC+: MA Maag Darm Lever (9)
Rok vydání: 2023
Předmět:
Zdroj: Journal of Alzheimer's Disease. IOS Press
ISSN: 1875-8908
1387-2877
Popis: BACKGROUND: If retinal indices of neurodegeneration are to be biomarkers for the monitoring of cerebral neurodegeneration, it is important to establish whether potentially modifiable risk factors for dementia are associated with retinal neurodegenerative changes.OBJECTIVE: To study associations of dementia risk factors with retinal sensitivity, an index of retinal neural function, and retinal nerve fiber layer (RNFL) thickness, an index of retinal neural structure.METHODS: We used cross-sectional data from The Maastricht Study (up to 5,666 participants, 50.5% men, mean age 59.7), and investigated associations with regression analyses (adjusted for potential confounders).RESULTS: Most risk factors under study (i.e., hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) were significantly associated with lower retinal sensitivity and lower RNFL thickness.CONCLUSION: Findings of this population-based study support the concept that retinal neural indices may be biomarkers for the monitoring of therapeutic strategies that aim to prevent early-stage cerebral neurodegeneration and, ultimately, dementia.
Databáze: OpenAIRE
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