Radiotherapy Enhancement for Human Pancreatic Carcinoma Using a Peptide-Gold Nanoparticle Hybrid
| Autor: | Jing Pang, Wenyu Dong, Xiao Han, Feng Wang, Ningyuan Tang, Fengming Lin, Weiran Zhang, Ting Lei, Jingjing Wang, Xiaoai Chang, Zhi Cai, Yaqin Zhang, Zhuoying Xie, Bin Qian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
0206 medical engineering Biomedical Engineering Metal Nanoparticles Pharmaceutical Science Medicine (miscellaneous) Bioengineering 02 engineering and technology Mice In vivo Cell Line Tumor Radioresistance medicine Animals Humans General Materials Science Chemistry Cancer 021001 nanoscience & nanotechnology medicine.disease 020601 biomedical engineering In vitro Pancreatic Neoplasms Radiation therapy Apoptosis Colloidal gold Cancer research Gold 0210 nano-technology Conjugate |
| Zdroj: | Journal of Biomedical Nanotechnology. 16:352-363 |
| ISSN: | 1550-7033 |
| DOI: | 10.1166/jbn.2020.2898 |
| Popis: | Pancreatic ductal adenocarcinoma (PDAC) is radioresistant. Due to their strong X-ray absorption capacity, gold nanoparticles (AuNPs) have been used as radiosensitizers for cancer therapeutics. Herein, we describe a novel conjugate complex consisting of a peptide for targeting plectin-1 (PTP) specifically expressed on the PDAC cell membrane and AuNPs, termed AuNP-PTP, to be used for PDAC radiotherapy in vitro and in vivo. Previous studies revealed that compared with unmodified AuNPs, AuNP-PTP along with relevant low-energy X-ray irradiation of 6 MV at a dose of 2 Gy (RF) increased the targeting efficiency and induced apoptosis in treated PANC-1 cells and tumours. Importantly, extensive histopathological examination did not reveal evidence of acute or chronic injury in mice due to AuNPs or AuNP-PTP for up to six weeks despite the presence of X-ray exposure. The delicate AuNP-PTP hybrid provides a novel strategy to enhance radiotherapy efficiency in PDAC treatment. |
| Databáze: | OpenAIRE |
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