Fibrin/fibrinogen Degradation Products Are Associated With Tumor Stage and Prognosis in Patients Undergoing Resection of Esophageal Cancer
| Autor: | Ken Shirabe, Hideyuki Saito, Arisa Yamaguchi, Shintaro Uchida, Akihiko Sano, Makoto Sakai, Takayoshi Watanabe, Takehiko Yokobori, Makoto Sohda, Nobuhiro Nakazawa, Yasunari Ubukata, Hiroomi Ogawa, Hiroshi Saeki, Kengo Kuriyama |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Fibrinogen Gastroenterology Fibrin Fibrin Fibrinogen Degradation Products Internal medicine Medicine Humans Stage (cooking) Pathological Neoadjuvant therapy Aged Neoplasm Staging Retrospective Studies biology business.industry General Medicine Esophageal cancer Middle Aged Plastic Surgery Procedures medicine.disease Prognosis Survival Analysis Up-Regulation Esophagectomy Treatment Outcome Oncology Tumor progression Multivariate Analysis biology.protein Female business medicine.drug |
| Zdroj: | Anticancer research. 41(9) |
| ISSN: | 1791-7530 |
| Popis: | Background/aim To investigate the significance of preoperative fibrin/fibrinogen degradation products (FDP) in patients with esophageal cancer (EC), we examined the association between the preoperative FDP level and clinicopathological features in patients with EC who underwent McKeown esophagectomy with gastric tube reconstruction without neoadjuvant therapy. Patients and methods Ninety patients with EC who underwent surgery between 2006 and 2014 were included in this study. We investigated the association of FDP levels with clinicopathological features and prognosis. Results Multivariate analysis revealed increased FDP level and pathological tumor depth to be independent prognostic factors for overall survival (OS) (p=0.008 and p=0.002, respectively). In addition, FDP levels were significantly positively associated with more advanced pathological TNM stage as a continuous variable (p for trend=0.002). Conclusion The preoperative FDP level was associated with a poor prognosis and was an independent prognostic factor for the OS of EC patients who underwent esophagectomy. Furthermore, the tumor stage-related increase in FDP indicated that a high FDP level is associated with tumor progression in patients with EC. |
| Databáze: | OpenAIRE |
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