Chronic Kidney Disease Is Associated with Increased Plasma Levels of Fibroblast Growth Factors 19 and 21
| Autor: | Kazimierz Ciechanowski, Barbara Dołęgowska, Maciej Domański, Małgorzata Marchelek-Myśliwiec, Violetta Dziedziejko, Andrzej Pawlik, Katarzyna Dolegowska, Monika Nowosiad-Magda, Krzysztof Safranow, Magda Wiśniewska, Joanna Stępniewska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system FGF21 030232 urology & nephrology Adipose tissue Renal function kidney transplantation fibroblast growth factor 21 urologic and male genital diseases lcsh:RC870-923 Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine lcsh:Dermatology Humans Medicine Renal Insufficiency Chronic Kidney transplantation fibroblast growth factor 19 body composition business.industry General Medicine Middle Aged lcsh:RL1-803 medicine.disease lcsh:Diseases of the genitourinary system. Urology female genital diseases and pregnancy complications adipose tissue Fibroblast Growth Factors Transplantation haemodialysis Nephrology lcsh:RC666-701 Lean body mass Female Cardiology and Cardiovascular Medicine business Body mass index chronic kidney disease Kidney disease |
| Zdroj: | Kidney & Blood Pressure Research, Vol 44, Iss 5, Pp 1207-1218 (2019) |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Background: Chronic kidney disease (CKD) is the result of a reduced number of nephrons, in which adipose tissue and its metabolites play a significant role. Fibroblast growth factors, FGF19 and FGF21, are involved in lipid and carbohydrate metabolism. The aim of the study was to examine the concentrations of FGF19 and FGF21 in patients with CKD, as well as the correlation between FGF19 and FGF21 and selected biochemical parameters. Materials and Methods: The study included 178 subjects: 52 patients with CKD in stages 2–4, without haemodialysis (CKD), 47 haemodialysed patients with CKD (HD), 56 patients with CKD after a renal transplantation (Tx) and 23 healthy subjects as the control group (C). Results: The highest FGF19 serum concentrations were observed in CKD patients and the lowest were observed in the Tx group. Patients in the CKD group had significantly higher serum FGF21 concentrations. There were negative correlations between FGF19 and glomerular filtration rate (GFR), as well as high-density lipoprotein cholesterol levels in patients after kidney transplantation. Negative correlations were also found between serum FGF21 concentrations and GFR in patients after Tx, while positive correlations were observed between FGF21 concentrations and lean body mass in the CKD group, body mass index and total cholesterol in the HD group. Conclusions: Our results suggest that increased concentrations of FGF19 and FGF21 in patients with CKD may be associated with the metabolism of lipids and carbohydrates. Our results also indicate that haemodialysis and transplantation results in the reduction of FGF19 and FGF21 concentrations in patients with CKD. |
| Databáze: | OpenAIRE |
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