Antibiotic treatment regimens for bone infection after debridement: a study of 902 cases
Autor: | Li Fang, Hongwen Zhao, Yueqi Chen, Zhao Xie, Xiaohua Wang, Shulin Wang, Huan Ma |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male Liver damage medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Adolescent medicine.drug_class medicine.medical_treatment Antibiotics Infections Bone Infection Fractures Bone Young Adult Postoperative Complications Rheumatology Recurrence Epidemiology Renal damage Humans Medicine Infection control Orthopedics and Sports Medicine Short-term antibiotic Child Aged Retrospective Studies Debridement Proteinuria business.industry Incidence (epidemiology) Middle Aged Anti-Bacterial Agents Surgery Treatment Outcome Child Preschool Female medicine.symptom lcsh:RC925-935 business Rifampicin Bone infection Research Article medicine.drug |
Zdroj: | BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-6 (2020) BMC Musculoskeletal Disorders |
ISSN: | 1471-2474 |
Popis: | Background Our aim was to investigate the clinical efficacy and complications of antibiotic treatment regimens for patients with bone infection. Methods We retrospectively analysed patients with bone infection admitted to our hospital between March 2013 and October 2018. After surgical debridement was performed, the patients were divided into three groups: IV group (intravenous antibiotics for 2 weeks); oral group (intravenous antibiotics for 2 weeks followed by oral antibiotics for 4 weeks); and rifampicin group (intravenous antibiotics for 2 weeks followed by oral antibiotics plus rifampicin for 4 weeks). The infection control rate and complications were compared among the three groups. Results A total of 902 patients were enrolled. The infection sites included 509 tibias, 228 femurs, 32 humeri, 23 radii and ulnae, 40 calcanei, and 47 miscellaneous sites, as well as 23 multiple-site infections. After at least 6 months of follow-up, 148 (16.4%) patients had an infection recurrence. The recurrence rate of the IV group was 17.9%, which was not significantly higher than the recurrence rates of the oral group (10.1%) and rifampicin group (10.5%), P = 0.051. The incidence of abnormal alanine aminotransferase (ALT) levels in the IV group was 15.1%, which was lower than that in the oral group (18.0%) and rifampicin group (27.4%), P = 0.026. The rates of proteinuria in the three groups were 3.2, 4.5, and 9.3%, respectively, P = 0.020. Conclusions After debridement of bone infection, short-term antibiotic treatment regimens might offer similar rates of infection eradication while avoiding the risk of renal and hepatic damage associated with prolonged antibiotic use. The level of clinical relevance Stage III. |
Databáze: | OpenAIRE |
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