Factors Associated With Increased Carotid Intima-Media Thickness and Being Nondipper in Nonobese and Normotensive Young Patients Affected by PCOS
Autor: | Hasan Fehmi Töre, Sengul Cehreli, Gurkan Is, Oya Caglar, Gurbuz Erdogan, Aslıhan Alhan, Sibel Ertek, Ebru Akgul Ercan, Efser Oztas, Arrigo F G Cicero |
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Přispěvatelé: | Akgul Ercan E., Ertek S., Is G., Caglar O., Oztas E., Cicero A., Alhan A., Cehreli S., Tore H.F., Erdogan G. |
Rok vydání: | 2011 |
Předmět: |
Adult
medicine.medical_specialty Ambulatory blood pressure endocrine system diseases Carotid Artery Common Blood Pressure Body Mass Index Young Adult Insulin resistance Internal medicine Blood pressure dipping PCOS medicine Humans cardiovascular diseases Ultrasonography Insulinresistance Carotid intima media thickne business.industry Hyperandrogenism Blood Pressure Monitoring Ambulatory medicine.disease Polycystic ovary Hormones Endocrinology Intima-media thickness Case-Control Studies Ambulatory cardiovascular system Female Insulin Resistance Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business Polycystic Ovary Syndrome |
Zdroj: | Angiology. 62:543-548 |
ISSN: | 1940-1574 0003-3197 |
DOI: | 10.1177/0003319711400183 |
Popis: | Polycystic ovary syndrome (PCOS) is characterized by chronic unovulation, hyperandrogenism, and insulin resistance. We evaluated factors that affect “nondipper” status during 24-hour ambulatory blood pressure monitoring (ABPM) and carotid intima-media thickness (cIMT) in PCOS. Forty-two nonobese women newly diagnosed as PCOS and 32 healthy women were included. After biochemical and hormonal measurements, the ovaries were imaged by pelvic ultrasonography and cIMT was measured by B-mode ultrasonography. A 24-hour ABPM was performed thereafter. Carotid IMT and the ratio of nondippers were elevated compared with controls. Homeostasis model assessment insulin resistance index (HOMA-IR) and low-density lipoprotein cholesterol (LDL-C) were found to be related with being a nondipper in PCOS. None of the parameters evaluated were found to correlate with cIMT. In conclusion, patients with PCOS had increased nondipping ratios and cIMT when compared with controls. Insulin resistance and LDL cholesterol are factors that are related to diurnal variation in normotensive and young patients with PCOS. |
Databáze: | OpenAIRE |
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