Protective effect of crocin on food azo dye tartrazine-induced hepatic damage by improving biochemical parameters and oxidative stress biomarkers in rats
| Autor: | Emrah Zayman, Zeynep Erdemli, Harika Gozukara Bag, Mehmet Gul, Mehmet Erman Erdemli, Cigdem Velioglu, Eyup Altinoz |
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| Přispěvatelé: | Velioglu, C., Department of Chemistry, Faculty of Science, Karabuk University, Karabuk, Turkey -- Erdemli, M.E., Department of Medical Biochemistry, Faculty of Medicine, Nigde Omer Halisdemir University, Nigde, Turkey -- Gul, M., Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey -- Erdemli, Z., Department of Medical Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey -- Zayman, E., Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey -- Bag, H.G., Department of Biostatistics, Faculty of Medicine, Inonu University, Malatya, Turkey -- Altinoz, E., Department of Medical Biochemistry, Faculty of Medicine, Karabuk University, Karabuk, Turkey, 0-Belirlenecek |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Physiology
Biophysics Pharmacology medicine.disease_cause Antioxidants Superoxide dismutase Crocin Random Allocation chemistry.chemical_compound medicine Animals Tartrazine biology ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS Hepatotoxicity Food Coloring Agents General Medicine Glutathione Free radical scavenger Malondialdehyde Carotenoids Rats ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ComputingMethodologies_PATTERNRECOGNITION Liver chemistry Oxidative stress biology.protein Alkaline phosphatase Chemical and Drug Induced Liver Injury InformationSystems_MISCELLANEOUS Biomarkers |
| Popis: | PubMed ID: 30657462 The objective of the present study was to demonstrate the protective effect of crocin on the adverse effects of tartrazine on liver. Crocin is a carotenoid and a strong free radical scavenger. Forty rats were randomly divided into 4 groups (n = 10). The first group was the control group (C) and saline solution was administered to this group. The second group (Cr) was administered 50 mg/ kg crocin. The third group (T) was administered 500 mg/kg tartrazine. The fourth group (T+Cr) was administered the same doses of both crocin and tartrazine as the previous groups for 21 days. It was determined that tartrazine increased liver superoxide dismutase (SOD) activity, malondialdehyde (MDA) and total oxidant status (TOS) levels and catalase (CAT) activity, decreased glutathione (GSH), and total antioxidant status (TAS) levels. Furthermore, tartrazine administration resulted in significant increases in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities and pathological changes in the liver. When tartrazine administered rats were treated with crocin for 21 days, the biochemical parameters improved, and liver tissues were restored. Thus, it was demonstrated that crocin had protective effects on the adverse effects caused by tartrazine administration. © 2019, Slovak Academy of Sciences. All rights reserved. Acknowledgement. The present study was sponsored by Karabuk University scientific research fund (KBU-BAP-16/2-YL-093). |
| Databáze: | OpenAIRE |
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