Haemophilus influenzae type b conjugate vaccine-induced immunological memory in symptomatic HIV-1-infected children
| Autor: | Vana G Papaevangelou, Glykeria Mostrou, Vana I. Spoulou, Maria Theodoridou, Dimitris L. Tsoumas |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Immunology
Immunization Secondary medicine.disease_cause Haemophilus influenzae Immune system Conjugate vaccine Immunopathology HIV Seropositivity Immunology and Allergy Medicine Humans Avidity Sida Child Haemophilus Vaccines biology business.industry Pasteurellaceae beta-Thalassemia Haemophilus influenzae type b biology.organism_classification Vaccination Infectious Diseases Case-Control Studies Child Preschool Immunoglobulin G HIV-1 business Immunologic Memory |
| Zdroj: | AIDS (London, England). 17(9) |
| ISSN: | 0269-9370 |
| Popis: | Haemophilus influenzae type b (Hib) conjugate vaccine-induced immunological memory was evaluated in all Greek symptomatic HIV-1-infected children. Patients had significantly lower anti-Hib polysaccharide IgG levels at one month, compared with controls [geometric mean concentration (μg/ml) 4.4 versus 41.24, P < 0.001]. Avidity declined post-vaccination and remained low thereafter. A second booster 18 months later failed to increase the concentration and avidity of polyribosylribitol phosphate. Immunological memory is impaired among symptomatic children and cannot be restored by repeated immunizations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|