An interpretation of the diffusion-type mechanism of drug release from microcapsules
| Autor: | Maria Angela Vandelli, Maria Teresa Bernabei, Gilberto Coppi, Flavio Forni |
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| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
Active ingredient
Chemistry Stereochemistry Microcapsule Salbutamol sulfate Spray-drying technique Drug release kinetics Diffusion-type mechanism Power law expression Drug release Pharmaceutical Science Value (computer science) Thermodynamics Salbutamol sulfate Power law Dosage form Diffusion type Interpretation (model theory) |
| Popis: | Salbutamol sulfate microcapsules were prepared by a spray-drying technique. The release data were calculated approximately via standard equations (square root and first-order relationships), but unequivocal evidence in support of the cumulative release mechanism was not obtained. Even more stringent mathematical or statistical (Durbin-Watson analysis) methods did not allow any distinction to be made between the two release mechanisms. In contrast, on application of the simple power law expression M t / M ∞ = kt n proposed by Peppas the value of the kinetic exponent of release (about 0.4) indicated a diffusion-type mechanism of the release process relative to the microcapsule shape. Therefore, it suggested here that this power law expression can be applied in order to confirm the actual diffusion-type mechanism of drug release from microcapsules. |
| Databáze: | OpenAIRE |
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