Pectin as Drug-Release Vehicle
| Autor: | Ali Assifaoui, Odile Chambin |
|---|---|
| Přispěvatelé: | Physico-Chimie de l'Aliment et du Vin (PCAV), Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, UFR des Sciences de Santé (Université de Bourgogne), Université de Bourgogne (UB) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
food.ingredient Pectin media_common.quotation_subject 02 engineering and technology engineering.material 010402 general chemistry Polysaccharide complex mixtures 01 natural sciences Dosage form food ComputingMilieux_MISCELLANEOUS media_common chemistry.chemical_classification Chromatography digestive oral and skin physiology food and beverages Chemical modification Buccal administration 021001 nanoscience & nanotechnology 0104 chemical sciences 3. Good health chemistry Drug delivery engineering Biopolymer 0210 nano-technology [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Pectin: Technological and Physiological Properties Pectin: Technological and Physiological Properties, Springer International Publishing, pp.189-207, 2020, 978-3-030-53420-2. ⟨10.1007/978-3-030-53421-9⟩ Pectin: Technological and Physiological Properties ISBN: 9783030534202 |
| DOI: | 10.1007/978-3-030-53421-9⟩ |
| Popis: | Pectin as a natural biopolymer is extensively used for pharmaceutical and biomedical applications, essentially due to its gelling properties that could be influenced by pectin sources and extraction methods. This chapter focuses on an overview of pectin drug delivery systems classified by their administration routes. Oral drug delivery systems have been mainly developed, as pectin could be used in tablets as binder or matrix excipients and in microparticles/beads obtained by ionotropic gelation. The main objective is to target the colon, as pectin is resistant in acidic pH and sensitive to pectinolytic enzymes in the colon. To obtain suitable properties, pectin could be used in its native state or after chemical modification and it could be also used in association with other compounds (e.g., polysaccharides, proteins, or silica). Mucous routes are also presented with examples of drug delivery systems for buccal, nasal, ocular, cutaneous and vaginal routes. Moreover, the gelling and mucoadhesive properties of pectin could be further exploited to improve the clinical efficacy of drug loaded in dosage forms. Finally, the parenteral route is presented with new developments due to good compatibility between biological cells and pectin and some recent studies about cancer are also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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