Motor evoked responses to paired cortical magnetic stimulation in Parkinson's disease
| Autor: | M. Santangelo, Antonio P. Strafella, D. Lucchi, A. Tropeani, Rocco Quatrale, D. De Grandis, F. Valzania, Carlo Alberto Tassinari |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Parkinson's disease Differential Threshold Stimulation Electromyography Stimulus (physiology) Inhibitory postsynaptic potential Levodopa Magnetics medicine Humans Evoked potential Aged Cerebral Cortex medicine.diagnostic_test business.industry General Neuroscience Parkinson Disease Middle Aged Evoked Potentials Motor medicine.disease Electric Stimulation medicine.anatomical_structure Female Silent period Neurology (clinical) business Neuroscience Motor cortex |
| Zdroj: | Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control. 105:37-43 |
| ISSN: | 0924-980X |
| Popis: | We evaluated cortical excitability in patients with Parkinson's disease (PD) using paired magnetic stimulation. This recent technique allows to study the cortical inhibition after motor evoked potential (MEP) and its modulation at different intensities of stimulation and interstimulus intervals (ISIs). At low stimulus intensity and at ISIs of 40-75 ms we observed, in PD patients, a greater test MEP inhibition, which might be due to a lower facilitatory effect of conditioning MEP on the motor cortex. At high stimulus intensity, in PD patients, a consistent inhibition of test MEP persisted and, at ISIs of 75-150 ms, it did not reach the amplitude of conditioning MEP as in normal subjects. Some clinical and neurophysiological features, like a silent period of shorter duration, demonstrated in PD patients a decrease of the inhibitory input to the motor cortex. On the contrary, the persistence of test-MEP inhibition at high stimulus intensity could also suggest a prevalence of inhibitory activity when an effective and phasic activation of the corticospinal system is required. |
| Databáze: | OpenAIRE |
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