Androgen receptor htSNPs in relation to androgen levels and OC use in young women from high-risk breast cancer families
| Autor: | Helena Jernström, Håkan Olsson, Therese Törngren, Maria Hietala, Maria Henningson |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Genetic Markers medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Genes BRCA2 Population Genes BRCA1 Dehydroepiandrosterone Breast Neoplasms Biology Polymorphism Single Nucleotide Biochemistry Young Adult chemistry.chemical_compound Endocrinology Dehydroepiandrosterone sulfate Breast cancer Risk Factors Internal medicine Genetics medicine Humans Young adult education Molecular Biology education.field_of_study Base Sequence Androgen medicine.disease Androgen receptor Contraceptives Oral Combined Haplotypes chemistry Receptors Androgen Cancer and Oncology Cohort Androgens Female Microsatellite Repeats |
| Zdroj: | Molecular Genetics and Metabolism; 102, pp 82-90 (2011) |
| ISSN: | 1096-7192 |
| DOI: | 10.1016/j.ymgme.2010.09.006 |
| Popis: | High testosterone levels have been associated with breast cancer. BRCA1 may function as an androgen receptor (AR) co-regulator. We aimed to examine AR haplotype-tagging single-nucleotide polymorphisms (AR htSNPs) and diplotypes in relation to in vivo androgen levels, combined OC use, CAG and GGC genotypes, and BRCA1/2/X family status in 269 young healthy women from breast cancer high-risk families and 56 additional BRCA1/2 mutation carriers. Testosterone, androstenedione, dehydroepiandrosterone sulfate, and body constitution were measured on cycle days 18-23. Six AR htSNPs and CAG and GGC repeat lengths were genotyped. Most OC users had lower androgen levels than non-users (all Ps |
| Databáze: | OpenAIRE |
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