Congenital lung abnormality quantification by computed tomography: The CLAQ method
| Autor: | Pierluigi Ciet, Johannes M. Schnater, Harm A.W.M. Tiddens, Jochem J. Bosch, Luis Riera, Rene M. H. Wijnen, Sergei M. Hermelijn, Olivier V. Dragt, Annelieke Hijkoop |
|---|---|
| Přispěvatelé: | Pediatric Surgery, Radiology & Nuclear Medicine, Pediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Male medicine.medical_specialty High-resolution computed tomography Adolescent congenital lung malformations Bronchogenic cyst Imaging high‐resolution computed tomography medicine congenital pulmonary airway malformation Humans Quantitative computed tomography Treadmill Child cystic adenomatoid malformation of lung Lung medicine.diagnostic_test business.industry congenital Infant Newborn Congenital pulmonary airway malformation Infant Original Articles medicine.disease medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Original Article Female Radiology Abnormality Respiratory System Abnormalities business Tomography X-Ray Computed |
| Zdroj: | Pediatric Pulmonology Pediatric Pulmonology, 55(11), 3152-3161. Wiley-Liss Inc. |
| ISSN: | 1099-0496 8755-6863 |
| Popis: | Introduction To date, no consensus has been reached on the optimal management of congenital lung abnormalities, and factors predicting postnatal outcome have not been identified. We developed an objective quantitative computed tomography (CT) scoring method, and assessed its value for clinical decision‐making. Methods Volumetric CT‐scans of all patients born with a congenital lung abnormality between January 1999 and 2018 were assessed. Lung disease was quantified using the newly‐developed congenital lung abnormality quantification (CLAQ) scoring method. In 20 equidistant axial slices, cells of a square grid were scored according to the abnormality within. The scored CT parameters were used to predict development of symptoms, and SD scores for spirometry and exercise tolerance (Bruce treadmill test) at 8 years of age. Results CT‐scans of 124 patients with a median age of 5 months were scored. Clinical diagnoses included congenital pulmonary airway malformation (49%), bronchopulmonary sequestration (27%), congenital lobar overinflation (22%), and bronchogenic cyst (1%). Forty‐four patients (35%) developed symptoms requiring surgery of whom 28 (22%) patients became symptomatic before a CT‐scan was scheduled. Lesional hyperdensity was found as an important predictor of symptom development and decreased exercise tolerance. Using receiver operating characteristic analysis, an optimal cut‐off value for developing symptoms was found at 18% total disease. Conclusion CT‐quantification of congenital lung abnormalities using the CLAQ method is an objective and reproducible system to describe congenital lung abnormalities on chest CT. The risk for developing symptoms may increase when more than a single lung lobe is affected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text