Evidence that Mouse Thyroid Stimulator does not Stimulate the Human Thyroid Gland
| Autor: | D. D. Adams, T. H. Kennedy, R. D. H. Stewart |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
endocrine system
medicine.medical_specialty Thyroid uptake endocrine system diseases business.industry Thyroid Thyroid Gland Hyperthyroidism Mice Endocrinology medicine.anatomical_structure Species Specificity Internal medicine Internal Medicine medicine Animals Humans Long-Acting Thyroid Stimulator Human thyroid business Mouse Thyroid Autoantibodies Iodine |
| Zdroj: | Australian and New Zealand Journal of Medicine. 6:300-304 |
| ISSN: | 0004-8291 |
| DOI: | 10.1111/imj.1976.6.4.300 |
| Popis: | Thyroid 131I uptake and human thyroid stimulator (HTS) level were measured in 20 untreated thyrotoxic patients who also showed mouse thyroid stimulator (MTS) ACtivity. The correlation between thyroid uptake and HTS level was highly significant (P less than 0-005), the coefficient, r, being 0-66, comparable with the value 0-68 obtained in a previous study of patients not showing MTS. Thus, the presence of widely varying amounts of MTS does not impair the close correlation existing between HTS level and thyroid 131I uptake in thyrotoxic people. There was no correlation between MTS level and thyroid 131I uptake (r = 0-11, n.s.). It is concluded that MTS, a potent stimulator of the thyroid glands of mice, guinea pigs and monkeys, does not stimulate the human thyroid gland. |
| Databáze: | OpenAIRE |
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