Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis
| Autor: | Ferenc Szalay, Bela Lombay, Miklós Udvardy, Peter L. Lakatos, Mária Papp, István Altorjay, István Tornai, Peter Orosz, Alajos Pár, Gabriella Pár, Sandor Kacska, Zsuzsanna Vitális, Gyula Farkas, Janos Osztovits, Timea Csak, Károly Palatka, Tamas Dinya, Antal Csepregi, Jolan Harsfalvi |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Liver Cirrhosis Male Time Factors Cirrhosis chemical and pharmacologic phenomena Autoimmune hepatitis Klinikai orvostudományok Mannose-Binding Lectin Cohort Studies Model for End-Stage Liver Disease Primary biliary cirrhosis Risk Factors medicine Humans Aged Proportional Hazards Models Mannan-binding lectin Hungary Hepatology business.industry Liver Diseases Orvostudományok Bacterial Infections Hepatitis C Middle Aged bacterial infections and mycoses medicine.disease MBL deficiency Immunity Innate Case-Control Studies Immunology Female business Viral hepatitis |
| Zdroj: | Journal of Hepatology. 53:484-491 |
| ISSN: | 0168-8278 |
| Popis: | Mannose-binding lectin (MBL) is a serum lectin synthesized by the liver and involved in innate host defense. MBL deficiency increases the risk of various infectious diseases mostly in immune-deficient conditions. Bacterial infections are a significant cause of morbidity and mortality in liver cirrhosis due to the relative immuncompromised state.Sera of 929 patients with various chronic liver diseases [autoimmune liver diseases (ALD), 406; viral hepatitis C (HCV), 185; and liver cirrhosis (LC) with various etiologies, 338] and 296 healthy controls (HC) were assayed for MBL concentration. Furthermore, a follow-up, observational study was conducted to assess MBL level as a risk factor for clinically significant bacterial infections in cirrhotic patients.MBL level and the prevalence of absolute MBL deficiency (100 ng/ml) was not significantly different between patients and controls (ALD: 14.5%, HCV: 11.9%, LC: 10.7%, HC: 15.6%). In cirrhotic patients, the risk for infection was significantly higher among MBL deficient subjects as compared to non-deficient ones (50.0% vs. 31.8%, p=0.039). In a logistic regression analysis, MBL deficiency was an independent risk factor for infections (OR: 2.14 95% CI: 1.03-4.45, p=0.04) after adjusting for Child-Pugh score, co-morbidities, gender, and age. In a Kaplan-Meier analysis, MBL deficiency was associated with a shorter time to develop the first infectious complication (median days: 579 vs. 944, pBreslow=0.016, pLogRank=0.027) and was identified as an independent predictor in a multivariate Cox-regression analysis (p=0.003, OR: 2.33, 95% CI: 1.34-4.03).MBL deficiency is associated with a higher probability and shorter time of developing infections in liver cirrhosis, further supporting the impact of the MBL molecule on the host defense. |
| Databáze: | OpenAIRE |
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