Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior
| Autor: | Anna Tchenio, Manuel Mameli, Salvatore Lecca, Julia J. Harris, Denis Burdakov, Frank J. Meye, Massimo Trusel, François Georges, Martin K. Schwarz |
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| Přispěvatelé: | Institut du Fer à Moulin, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Pharmacology, University of Cambridge [UK] (CAM), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Institut du Fer à Moulin (IFM - Inserm U1270 - SU), Université de Lausanne (UNIL), University Medical Center [Utrecht], The Francis Crick Institute [London], University of Bonn, Interdisciplinary Institute for Neuroscience (IINS), Georges, Francois, Université de Lausanne = University of Lausanne (UNIL) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male endocrine system Lateral hypothalamus Mouse QH301-705.5 in vivo physiology Science [SDV]Life Sciences [q-bio] [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Short Report Hypothalamus Action Potentials Escape response Animals Behavior Animal Electroencephalography Escape Reaction Habenula/physiology Hypothalamus/physiology Mice Inbred C57BL Neural Pathways aversion habenula mouse neuroscience Biology General Biochemistry Genetics and Molecular Biology Midbrain 03 medical and health sciences Glutamatergic 0302 clinical medicine Biological neural network Biology (General) ComputingMilieux_MISCELLANEOUS Habenula [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior General Immunology and Microbiology [SDV.BA]Life Sciences [q-bio]/Animal biology General Neuroscience General Medicine Anatomy 030104 developmental biology Medicine Aversive Stimulus Neuroscience 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists |
| Zdroj: | eLife eLife, eLife Sciences Publication, 2017, 6, ⟨10.7554/eLife.30697⟩ eLife, 2017, 6, ⟨10.7554/eLife.30697⟩ eLife, eLife Sciences Publication, 2017, 6, pp.e30697. ⟨10.7554/eLife.30697⟩ eLife, vol. 6, pp. 1-16 eLife, Vol 6 (2017) eLife, 2017, 6, pp.e30697. ⟨10.7554/eLife.30697⟩ |
| ISSN: | 2050-084X |
| Popis: | International audience; A sudden aversive event produces escape behaviors, an innate response essential for survival in virtually all-animal species. Nuclei including the lateral habenula (LHb), the lateral hypothalamus (LH), and the midbrain are not only reciprocally connected, but also respond to negative events contributing to goal-directed behaviors. However, whether aversion encoding requires these neural circuits to ultimately prompt escape behaviors remains unclear. We observe that aversive stimuli, including foot-shocks, excite LHb neurons and promote escape behaviors in mice. The foot-shock-driven excitation within the LHb requires glutamatergic signaling from the LH, but not from the midbrain. This hypothalamic excitatory projection predominates over LHb neurons monosynaptically innervating aversion-encoding midbrain GABA cells. Finally, the selective chemogenetic silencing of the LH-to-LHb pathway impairs aversion-driven escape behaviors. These findings unveil a habenular neurocircuitry devoted to encode external threats and the consequent escape; a process that, if disrupted, may compromise the animal’s survival. |
| Databáze: | OpenAIRE |
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