Emerging role of plumbagin: Cytotoxic potential and pharmaceutical relevance towards cancer therapy
| Autor: | Bijesh K. Biswal, Munmun Panda, Surya Kant Tripathi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
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Cell cycle checkpoint Cell Survival Apoptosis Toxicology 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Cell Line Tumor Neoplasms Animals Humans Cytotoxicity Protein kinase B Cell Proliferation 030304 developmental biology 0303 health sciences Autophagy Cell Cycle Checkpoints 04 agricultural and veterinary sciences General Medicine Plumbagin Antineoplastic Agents Phytogenic 040401 food science chemistry Cancer cell Cancer research Female Signal transduction Reactive Oxygen Species Naphthoquinones Signal Transduction Food Science |
| Zdroj: | Food and Chemical Toxicology. 125:566-582 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2019.01.018 |
| Popis: | Plumbagin is a naphthoquinone derived yellow crystalline phytochemical. Plumbagin has a wide range of biological effects including cytotoxicity against cancer cells both in vitro and in vivo. Due to the pleiotropic nature of plumbagin, it shows the anticancer effect by targeting several molecular mechanisms including apoptosis and autophagic pathways, cell cycle arrest, anti-angiogenic pathways, anti-invasion and anti-metastasis pathways. Among many signaling pathways the key regulatory genes regulated by plumbagin are NF-kβ, STAT3, and AKT, etc. Plumbagin is also a potent inducer of ROS, suppressor of cellular glutathione, and causes DNA strand break by oxidative DNA base damages. In vivo studies suggested that plumbagin significantly reduces the tumor weight and volume in dose-dependent manner without any side effects in tested model organisms. Another exciting aspect of plumbagin is the ability to re-sensitize the chemo and radioresistant cancer cells when used in combination or alone. Nano encapsulation of plumbagin overcomes the poor water solubility and bioavailability obstacles, enhancing the pharmaceutical relevance with better therapeutic efficacy. Moreover, plumbagin can be introduced as a future phytotherapeutic anticancer drug after fully satisfied preclinical and clinical trials. |
| Databáze: | OpenAIRE |
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