Estimated Lean Body Mass Is More Appropriate than Body Surface Area for Scaling Glomerular Filtration Rate and Extracellular Fluid Volume
| Autor: | Nicholas J. Bird, Shirley Love, A. Michael Peters, Hayley Snelling, Daphne M. Glass |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Body Surface Area Body water Adult population Urology 51cr edta Renal function urologic and male genital diseases Body Mass Index Young Adult Absorptiometry Photon Thinness Internal medicine Extracellular fluid Humans Medicine Child Aged Body surface area urogenital system business.industry Extracellular Fluid General Medicine Middle Aged Body Fluids Endocrinology Nephrology Child Preschool Lean body mass Linear relation Female business Glomerular Filtration Rate |
| Zdroj: | Nephron Clinical Practice. 116:c75-c80 |
| ISSN: | 1660-2110 |
| DOI: | 10.1159/000314666 |
| Popis: | Background/Aims: To compare body surface area (BSA) with lean body mass (LBM) for scaling extracellular fluid volume (ECV) and glomerular filtration rate (GFR). Methods:Phase 1: Total body water (TBW), bromide space and LBM were measured with 3H-water, 77Br and dual X-ray absorptiometry, respectively, in 6 healthy adults. Phase 2: ECV and GFR were measured with 51Cr-EDTA in 95 healthy adults and 56 children (0.5–13 years). ECV was calculated as GFR divided by GFR/ECV, both corrected for the one-compartment assumption. LBM was estimated (eLBM) in adults from height and weight and in children using a height/weight formula for estimating ECV and a constant derived from a separate adult population relating ECV to eLBM. Results:Phase 1: LBM and BSA correlated closely with TBW and bromide space. With LBM, the regressions passed through the origin, but with BSA, the intercepts were significantly below zero. Phase 2: GFR/BSA and ECV/BSA were higher in men than women but no difference was recorded in GFR/eLBM, GFR/ECV or ECV/eLBM. ECV showed a linear relation with eLBM and a non-linear relation with BSA. GFR/BSA and ECV/BSA correlated significantly with BSA but neither GFR/eLBM nor ECV/eLBM correlated with eLBM. Conclusion: eLBM is preferable to BSA for scaling GFR and ECV. |
| Databáze: | OpenAIRE |
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