Erratum: Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance
| Autor: | Martin Dale, Philipp E. Scherer, Yi Hui Phua, Lee D. Roberts, Francisco J. Tinahones, Julian L. Griffin, Steven A. Murfitt, Chong Yew Tan, Antonio Vidal-Puig, Samuel Virtue |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty Degree of unsaturation Multidisciplinary Adipose tissue Fatty acid food and beverages Biology medicine.disease Obesity Article 03 medical and health sciences Chain length 030104 developmental biology Insulin resistance Endocrinology chemistry Biochemistry Internal medicine medicine lipids (amino acids peptides and proteins) |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The non-essential fatty acids, C18:1n9, C16:0, C16:1n7, C18:0 and C18:1n7 account for over 75% of fatty acids in white adipose (WAT) triacylglycerol (TAG). The relative composition of these fatty acids (FA) is influenced by the desaturases, SCD1-4 and the elongase, ELOVL6. In knock-out models, loss of SCD1 or ELOVL6 results in reduced Δ9 desaturated and reduced 18-carbon non-essential FA respectively. Both Elovl6 KO and SCD1 KO mice exhibit improved insulin sensitivity. Here we describe the relationship between WAT TAG composition in obese mouse models and obese humans stratified for insulin resistance. In mouse models with increasing obesity and insulin resistance, there was an increase in scWAT Δ9 desaturated FAs (SCD ratio) and FAs with 18-carbons (Elovl6 ratio) in mice. Data from mouse models discordant for obesity and insulin resistance (AKT2 KO, Adiponectin aP2-transgenic), suggested that scWAT TAG Elovl6 ratio was associated with insulin sensitivity, whereas SCD1 ratio was associated with fat mass. In humans, a greater SCD1 and Elovl6 ratio was found in metabolically more harmful visceral adipose tissue when compared to subcutaneous adipose tissue. |
| Databáze: | OpenAIRE |
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