Abnormal B-cell function in hemophiliacs treated with cryoprecipitate and factor VIII and IX concentrates
| Autor: | George F. Gjerset, Richard B. Counts, John A. Hansen, Andrew Gorski, Paul J. Martin |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Adolescent Immunology Hemolytic Plaque Technique Hemophilia A Fibrinogen Hemophilia B Immunoglobulin secretion Immunoglobulin G Virus Pathology and Forensic Medicine Factor IX medicine Coagulopathy Humans Immunology and Allergy Child Aged B-Lymphocytes Factor VIII biology business.industry Middle Aged medicine.disease Cryoprecipitate biology.protein Antibody business medicine.drug |
| Zdroj: | Clinical Immunology and Immunopathology. 40:447-455 |
| ISSN: | 0090-1229 |
| DOI: | 10.1016/0090-1229(86)90189-3 |
| Popis: | B-Cell function was evaluated in a group of 43 patients with factor VIII or factor IX deficiency. Thirty had been treated primarily with cryoprecipitate and 13 with concentrates of factor VIII or IX. Serum immunoglobulin G levels were found to be diffusely elevated; however, the absolute number of mature B cells in peripheral blood was normal. B-Cell function as measured by testing mitogen-induced proliferation and and immunoglobulin secretion by plaque-forming cells (PFC) in vitro was reduced. Coculture experiments suggested that these abnormal B-cell responses might be secondary to increased suppressor T-cell activity, which was found more frequently in patients seropositive for antibody to lymphadenopathy-associated virus. Both seronegative and seropositive patients had reduced responses in the proliferative and PFC assays, but the lowest PFC responses occurred in the seropositive group. |
| Databáze: | OpenAIRE |
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