Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study

Autor:	Rei Otsuka, Naoko Kawano, Hisao Naito, Masako Shimoda, Takeshi Nakagawa, Atsuhiko Ota, Yoshihisa Hirakawa, Masaaki Matsunaga, Hiroya Yamada, Naohiro Ichino, Kayo Kaneko, Atsuko Aoyama, Chifa Chiang, Koji Tamakoshi, Hiroshi Yatsuya
Rok vydání:	2023
Předmět:	medicine.medical_specialty Epidemiology business.industry Confounding Montreal Cognitive Assessment General Medicine Odds ratio Impaired fasting glucose medicine.disease Middle age Internal medicine Diabetes mellitus medicine business Body mass index Cohort study
Zdroj:	Journal of Epidemiology. 33:76-81
ISSN:	1349-9092 0917-5040
Popis:	Background There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function (assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers' Cohort Study in Japan. Methods Participants were 253 former local government employees aged 60-79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate. Results The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29. Conclusions FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95334299d836ee1bebc1e285942f5d85 https://doi.org/10.2188/jea.je20210128 Zobrazit plný text záznamu