Antagonism of the Gut-Contracting Effects of Bombesin and Neurotensin by Opioid Peptides, Morphine, Atropine or Tetrodotoxin
| Autor: | G. Zetler |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Atropine
Guinea Pigs Tetrodotoxin Pharmacology digestive system chemistry.chemical_compound Ileum Animals Medicine Opioid peptide Neurotensin Neurons Morphine Naloxone business.industry musculoskeletal neural and ocular physiology digestive oral and skin physiology Bombesin General Medicine nervous system chemistry Anesthesia Peptides business Antagonism hormones hormone substitutes and hormone antagonists Muscle Contraction medicine.drug |
| Zdroj: | Pharmacology. 21:348-354 |
| ISSN: | 1423-0313 0031-7012 |
| Popis: | Morphine, met-enkephalin, beta-endorphin, tetrodotoxin (TTX), and atropine antagonized the gut-contracting effects of the peptides neurotensin and bombesin. The opioids and TTX shifted the concentration-response curves to the right and mostly depressed the maximum response to the agonists; atropine caused only depression of the maximum. Morphine was more potent than the opioid peptides. Naloxone did not modify the effects of neurotensin and bombesin. However, it completely abolished the antagonistic effects of the opioids, but not that of atropine. In conclusion, neurotensin and bombesin stimulate the intramural neurons via a process that is inhibited by the activation of opioid receptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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