Pirocarbotrat: a new radiopharmaceutical for the treatment of solid tumors--comparative studies in N-nitrosomethylurea-induced rat mammary tumors
| Autor: | José Boccio, Marcela Zubillaga, J.O. Nicolini, R. Ughetti, Ricardo A. Caro, E. Lanari |
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| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
Biodistribution medicine.medical_treatment Mammary gland Brachytherapy Urine Pharmacology Pyrophosphate Rats Sprague-Dawley chemistry.chemical_compound medicine Distribution (pharmacology) Animals Radiology Nuclear Medicine and imaging business.industry Mammary Neoplasms Experimental Methylnitrosourea Phosphorus-32 Beta Particles Rats Radiation therapy Diphosphates medicine.anatomical_structure chemistry Charcoal Molecular Medicine Gelatin Female business Nuclear medicine Phosphorus Radioisotopes |
| Zdroj: | Nuclear medicine and biology. 24(6) |
| ISSN: | 0969-8051 |
| Popis: | To evaluate the effectiveness of a single intratumoral dose of Pirocarbotrat ™ , a gelatinprotected charcoal suspension labeled with chromic [ 32 P]pyrophosphate, studies of bioelimination, biodistribution and therapeutic action were carried out in rats, and the results obtained were compared with those of other 32 P dispersions. We found that 78.3% of the treated tumors reduced size after 32 days of treatment. At that time, the total eliminated activity was 12.70 ± 3.90% distributed in urine (8.30 ± 1.80%) and feces (4.40 ± 3.50%). Biodistribution studies demonstrate that 84.50 ± 2.60% of the injected activity remained in the tumor, with no significant concentration in the rest of the organism. We conclude that Pirocarbotrat ™ can be used as a safe agent for brachytherapy of solid tumors with β particles. |
| Databáze: | OpenAIRE |
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