Fecal Markers of Inflammation and Disease Activity in Paediatric Crohn's Disease : results from the ImageKids Study
| Autor: | Andrew S. Day, Anne M. Griffiths, David R. Mack, Malgorzata Sladek, Steven T. Leach, Víctor Manuel Navas-López, Rachel Messenger, Anthony R. Otley, Daniel A. Lemberg, Annecarin Brückner, Baruch Yerushalmi, Thomas D. Walters, Dan Turner, Matan Gavish, Shehzad Ahmed Saeed |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Adolescent Colonoscopy Inflammatory bowel disease Gastroenterology Severity of Illness Index 03 medical and health sciences Feces 0302 clinical medicine Osteoprotegerin Crohn Disease Interquartile range 030225 pediatrics Internal medicine Severity of illness medicine Humans Prospective Studies Prospective cohort study Child Inflammation medicine.diagnostic_test business.industry medicine.disease Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
| Popis: | Background Noninvasive and accurate methods to monitor inflammatory bowel disease are required. As a planned ancillary study of the prospective ImageKids cohort, we aimed to assess the performance of fecal calprotectin (FC) with comparison to 3 fecal inflammatory markers; S100A12 (FA12), tumor pyruvate kinase isoenzyme type M2 (FM2PK) and fecal osteoprotegerin (FOPG) as indicators of a number of disease characteristics. Methods The ImageKids study was a multicenter study designed to develop 2 magnetic resonance enterography-based measures for children with Crohn disease (6-18 years old). All patients underwent magnetic resonance enterography, a complete ileocolonoscopic evaluation and provided a fecal sample. Fecal samples were assay for FC, FA12, FM2PK, and FOPG by ELISA. Results One-hundred fifty-six children provided 190 fecal samples. Median (interquartile range) for fecal makers were FC, 602 (181-1185) μg/g; FA12, 21 (3-109) μg/g; FM2PK, 16 (2-20) U/mL; and FOPG, 125 (125-312) μg/g. All markers correlated with simple endoscopic severity index for Crohn disease and with other constructs of disease activity, but FC had the highest overall correlations. FA12, however, predicted mucosal healing with significantly higher specificity (87% vs 70%, P = 0.004) and equivalent sensitivity (91% vs 90%) compared to FC. Conclusion This study has confirmed that FC is useful, and overall best, marker to monitor mucosal inflammation in inflammatory bowel disease. FA12, however, appears to be a more suitable maker for prediction of mucosal healing in children. |
| Databáze: | OpenAIRE |
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