PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathwayin vitro

Autor: Xiaoyan Lv, Ye Chen, Zhongguo Hu, Yidong Wang, Ruizhi Tan, Yuhang Liu, Hong Guo, Qin Zhou, Zheng Zhang, Chun Ye, Ke Zhang, Rong Zheng
Rok vydání: 2007
Předmět:
Zdroj: Cell Biochemistry and Function. 25:767-774
ISSN: 1099-0844
0263-6484
DOI: 10.1002/cbf.1417
Popis: The approximately 14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large ( approximately 460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes.
Databáze: OpenAIRE