PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathwayin vitro
Autor: | Xiaoyan Lv, Ye Chen, Zhongguo Hu, Yidong Wang, Ruizhi Tan, Yuhang Liu, Hong Guo, Qin Zhou, Zheng Zhang, Chun Ye, Ke Zhang, Rong Zheng |
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Rok vydání: | 2007 |
Předmět: |
DNA
Complementary TRPP Cation Channels Blotting Western Clinical Biochemistry Autosomal dominant polycystic kidney disease Gene Expression Wnt1 Protein Biology Transfection urologic and male genital diseases Biochemistry Cell Movement Cell Line Tumor Neoplasms Cell Adhesion medicine Polycystic kidney disease Humans Neoplasm Invasiveness beta Catenin Cell Aggregation Glycoproteins PKD1 urogenital system Intracellular Signaling Peptides and Proteins Wnt signaling pathway LRP6 LRP5 Cell migration Cell Biology General Medicine Cadherins medicine.disease female genital diseases and pregnancy complications Cell biology Cancer cell Cancer research Signal Transduction |
Zdroj: | Cell Biochemistry and Function. 25:767-774 |
ISSN: | 1099-0844 0263-6484 |
DOI: | 10.1002/cbf.1417 |
Popis: | The approximately 14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large ( approximately 460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes. |
Databáze: | OpenAIRE |
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