Effects of Phenobarbital on Hypothalamic LHRH and Catecholamine Turnover Rates in Proestrous Rats
| Autor: | Naomi Rance, Charles A. Barraclough |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Dopamine Hypothalamus General Biochemistry Genetics and Molecular Biology Gonadotropin-Releasing Hormone Norepinephrine (medication) Norepinephrine Catecholamines Estrus Pituitary Gland Anterior Pregnancy Internal medicine medicine Animals Castration Morning Estradiol Chemistry Luteinizing Hormone Prolactin Rats Endocrinology Barbiturate Phenobarbital Median eminence Catecholamine Female Proestrus hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 166:425-431 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-166-41085 |
| Popis: | In previous studies we observed that LHRH concentrations increase in the preoptic-suprachiasmatic tuberoinfundibular system (PSTS) during the morning hours of proestrus when norepinephrine (NE) and dopamine (DA) turnover rates are low. Concomitant with the preovulatory surge in gonadotropins, NE turnover rates increase, DA turnovers decrease, and LHRH declines in PSTS. The present studies examine the effects of phenobarbital (PB) on these proestrous events. PB, when given at 0900 hr proestrus, does not prevent the rise in median eminence (ME) LHRH which occurs between 0900 and 1200 hr. When the barbiturate is administered at 1200 hr, LH, FSH, and prolactin proestrous surges are blocked. While PB (given at 1200 hr) does not affect the increase in turnover rates of NE and DA which occur between 1200 and 1400 hr proestrus it markedly suppressed NE turnover rates in ME and suprachiasmatic nuclei but not in the medial preoptic nuclei between 1500 and 1700 hr. The decline in ME-DA which occurs between 1... |
| Databáze: | OpenAIRE |
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