Brain volumes and risk of cardiovascular events and mortality. The SMART-MR study
| Autor: | Veen, P.H. van der, Muller, M., Vincken, K.L., Mali, W.P.T.M., Graaf, Y. van der, Geerlings, M.I., SMART Study Grp |
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| Přispěvatelé: | Internal medicine, NCA - neurodegeneration |
| Rok vydání: | 2014 |
| Předmět: |
Male
Risk Aging medicine.medical_specialty Time Factors Epidemiology Population Brain imaging Cohort Studies Cardiovascular events Cerebrospinal fluid Atrophy Risk Factors Cause of Death Internal medicine medicine Humans Dementia Brain segmentation Mortality Cognitive decline education education.field_of_study business.industry General Neuroscience Hazard ratio Cohort Brain Organ Size Prognosis Atherosclerosis medicine.disease Magnetic Resonance Imaging Surgery Stroke Cardiovascular Diseases Brain size Cardiology Female Neurology (clinical) Geriatrics and Gerontology business Follow-Up Studies Developmental Biology |
| Zdroj: | Neurobiology of Aging, 35(7), 1624-1631. Elsevier Inc. Neurobiology of Aging, 35(7), 1624-1631 van der Veen, P H, Muller, M, Vincken, K L, Mali, W P T M, van der Graaf, Y & Geerlings, M I 2014, ' Brain volumes and risk of cardiovascular events and mortality. The SMART-MR study ', Neurobiology of Aging, vol. 35, no. 7, pp. 1624-1631 . https://doi.org/10.1016/j.neurobiolaging.2014.02.003 |
| ISSN: | 0197-4580 |
| Popis: | Brain atrophy is a strong predictor for cognitive decline and dementia, and these are, in turn, associated with increased mortality in the general population. Patients with cardiovascular disease have more brain atrophy and a higher morbidity and mortality. We investigated if brain volumes on magnetic resonance imaging were associated with the risk of cardiovascular events and mortality in patients with manifest arterial disease (n = 1215; mean age 58 years). Automated brain segmentation was used to quantify intracranial volume, and volumes of total brain, sulcal cerebrospinal fluid, and ventricles. After a median follow-up of 8.3 years, 184 patients died, 49 patients had an ischemic stroke, and 100 patients had an ischemic cardiac complication. Smaller relative brain volumes increased the risk of all-cause death (hazard ratio [HR] per standard deviation decrease in total brain volume: 1.58, 95% confidence interval [95% CI]: 1.33-1.88), vascular death (HR 1.69, 95% CI: 1.35-2.13), and ischemic stroke (HR 1.96, 95% CI: 1.43-2.69), independent of cardiovascular risk factors. These results suggest that brain volumes are an important determinant of poor outcome in patients with high cardiovascular risk. |
| Databáze: | OpenAIRE |
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