DEMYELINATION INDUCED IN MICE BY AVIRULENT SEMLIKI FOREST VIRUS. I. VIROLOGY AND EFFECTS ON OPTIC NERVE
| Autor: | Snehlata Pathak, H. E. Webb, S. J. Illavia |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Optic Neuritis Histology genetic structures Central nervous system Avirulent strain Semliki Forest virus Virus Pathology and Forensic Medicine law.invention Mice Togaviridae Infections law Physiology (medical) medicine Animals Retina biology Optic Nerve biology.organism_classification Semliki forest virus Virology eye diseases Disease Models Animal medicine.anatomical_structure Neurology Optic nerve ON - Optic nerve Female sense organs Neurology (clinical) Electron microscope Demyelinating Diseases |
| Zdroj: | Neuropathology and Applied Neurobiology. 8:35-42 |
| ISSN: | 1365-2990 0305-1846 |
| DOI: | 10.1111/j.1365-2990.1982.tb00255.x |
| Popis: | Swiss A2G mice were infected intraperitoneally with an avirulent strain of Semliki Forest virus. The virus titres in the optic nerves, retina and brain were estimated on post-inoculation days 3 to 8. High titres of virus were obtained in the optic nerve, retina and brain. The optic nerves, retina and brain were studied by light microscopy up to post-inoculation day 67. Electron microscope studies wee carried out on the optic nerve on post-inoculation days 11 and 14. Inflammatory, microcystic changes and demyelination seen in the optic nerve were similar to those found in he central nervous system. |
| Databáze: | OpenAIRE |
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