Dichotomous miR expression and immune responses following primary blood-stage malaria
| Autor: | Christine Langer, Julie G. Burel, Michelle J. Boyle, Denise L. Doolan, James S. McCarthy, Penny Groves, Simon H. Apte, James G. Beeson |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
biology Plasmodium falciparum General Medicine medicine.disease biology.organism_classification 3. Good health Vaccination 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Immunity Immunology microRNA medicine biology.protein Antibody 030217 neurology & neurosurgery Malaria Research Article Whole blood |
| Zdroj: | JCI Insight. 2 |
| ISSN: | 2379-3708 |
| Popis: | Clinical responses to infection or vaccination and the development of effective immunity are characterized in humans by a marked interindividual variability. To gain an insight into the factors affecting this variability, we used a controlled human infection system to study early immune events following primary infection of healthy human volunteers with blood-stage Plasmodium falciparum malaria. By day 4 of infection, a dichotomous pattern of high or low expression of a defined set of microRNAs (miRs) emerged in volunteers that correlated with variation in parasite growth rate. Moreover, high-miR responders had higher numbers of activated CD4+ T cells, and developed significantly enhanced antimalarial antibody responses. Notably, a set of 17 miRs was identified in the whole blood of low-miR responders prior to infection that differentiated them from high-miR responders. These data implicate preexisting host factors as major determinants in the ability to effectively respond to primary malaria infection. |
| Databáze: | OpenAIRE |
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