Angiotensin II provokes cesium-induced ventricular tachyarrhythmias
| Autor: | Hideko Nakashima, Naoki Gondo, Koichiro Kumagai, Keijiro Saku |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Captopril Physiology medicine.medical_treatment Action Potentials Cesium Angiotensin-Converting Enzyme Inhibitors Ventricular tachycardia Afterdepolarization Electrocardiography Random Allocation Dogs Physiology (medical) Infusion Procedure Medicine Animals cardiovascular diseases Enzyme Inhibitors Estrenes Saline Analysis of Variance biology business.industry Angiotensin II Fissipedia Hemodynamics biology.organism_classification medicine.disease Pyrrolidinones Anesthesia Type C Phospholipases Ventricular fibrillation Models Animal Tachycardia Ventricular Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | Cardiovascular research. 49(2) |
| ISSN: | 0008-6363 |
| Popis: | Objective: The purpose of this study was to investigate whether angiotensin II provokes ventricular tachyarrhythmias and to clarify its mechanism using the cesium-induced arrhythmia model, which has been widely used as an afterdepolarization and triggered activity model. Methods: Eighteen adult mongrel dogs of either sex weighing 9.6–23.0 kg were studied. The dogs were randomly divided into three groups. In the control group ( n = 6), the subjects received intravenous saline solution at a 0.45 ml/kg/h, and intravenous bolus injections of cesium (0.25, 0.5, 1.0 mmol/kg) were given at 20-min intervals. In the captopril-treated group ( n = 6), captopril was administered intravenously at 15 μg/kg/min, and cesium was injected as above. After the infusion of only captopril, in the captopril-treated group, angiotensin II was simultaneously infused at a dose of 0.1 ng/kg/min, and cesium was injected as above. When the dog survived, the dose of angiotensin II was increased to 1.0 ng/kg/min, and the same procedure was repeated. The remaining six dogs were simultaneously infused with captopril (15 μg/kg/min), angiotensin II (1.0 ng/kg/min), and U-73122 (10 μg/kg/min), a selective phospholipase C blocker, and injected with cesium (1.0 mmol/kg). Forty minutes after termination of U-73122 infusion, the dogs were injected with the same dose of cesium. Results: Sustained ventricular tachycardia or ventricular fibrillation was induced by cesium in all of the dogs in the control group. In the captopril-treated group, none of the dogs showed these arrhythmias when only captopril was infused. The treatment of captopril significantly reduced lethal arrhythmias ( P |
| Databáze: | OpenAIRE |
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