Evaluation of HIV-specific T-cell responses in HIV-infected older patients with controlled viremia on long-term antiretroviral therapy

Autor:	Anne M. Wertheimer, Stephen A. Klotz, Maria Love, Nicole E. Behrens, Nafees Ahmad
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male 0301 basic medicine RNA viruses Viral Diseases T-Lymphocytes CD4-CD8 Ratio HIV Infections Pathology and Laboratory Medicine Granzymes White Blood Cells 0302 clinical medicine Medical Conditions Immunodeficiency Viruses Animal Cells Cellular types Medicine and Health Sciences Medicine Public and Occupational Health Aged 80 and over Multidisciplinary T Cells Immune cells virus diseases Middle Aged Viral Load Vaccination and Immunization medicine.anatomical_structure Infectious Diseases Anti-Retroviral Agents Medical Microbiology Viral Pathogens Viruses Female Tumor necrosis factor alpha medicine.symptom Pathogens Viral load Research Article Adult Cell biology Blood cells Science T cell Immunology Cell Enumeration Techniques Antiretroviral Therapy Inflammation Viremia Cytotoxic T cells Research and Analysis Methods Microbiology Interferon-gamma 03 medical and health sciences Immune system Antiviral Therapy Lysosomal-Associated Membrane Protein 1 Virology Retroviruses Humans Microbial Pathogens Aged Biology and life sciences Tumor Necrosis Factor-alpha business.industry Lentivirus Organisms HIV medicine.disease 030104 developmental biology Age Groups People and Places Population Groupings Preventive Medicine business CD8 Viral Transmission and Infection 030215 immunology
Zdroj:	PLoS ONE PLoS ONE, Vol 15, Iss 9, p e0236320 (2020)
ISSN:	1932-6203
Popis:	HIV-infected older individuals may have a diminished immune response because of exhaustion/immune aging of T-cells. Therefore, we have investigated HIV-specific CD4 and CD8 T-cell responses in 100 HIV-infected patients (HIV+) who have aged on long-term antiretroviral therapy (ART) and achieved controlled viremia (mostly undetectable viral load; 92 patients with
Databáze:	OpenAIRE
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